Front Cover: Andrographolide Derivatives Target the KEAP1/NRF2 Axis and Possess Potent Anti‐SARS‐CoV‐2 Activity (ChemMedChem 5/2022)
نویسندگان
چکیده
The Front Cover illustrates the natural product andrographolide, which modulates abundance of transcription factor NRF2, a substrate E3 ligase KEAP1. Previous studies identified that this drug possessed anti-SARS-CoV-2 activity, but mechanism action remained unclear. authors designed and synthesized novel andrographolide derivatives with functional site to fine-tune physicochemical properties for linker attachment. team assayed new set compounds in cell-based NRF2 reporter gene assay determined their ability decrease infectivity virus-treated Vero-E6 cells. Data showed activation by inhibition SARS-CoV-2 replication correlated well. study opens avenues investigate products target KEAP1/NRF2 axis as agents. More information can be found Research Article Christian Steinebach et al.
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ژورنال
عنوان ژورنال: ChemMedChem
سال: 2022
ISSN: ['1860-7179', '1860-7187']
DOI: https://doi.org/10.1002/cmdc.202200088